About
Ph.D. in Bioinformatics from the University of Tokyo, supervised by Professor Kenta Nakai. Research focuses on cancer biology, single-cell and spatial multi-omics. Interests include integrative analysis of cancer multi-omics data and the development of computational methods for studying tumor heterogeneity and microenvironmental dynamics.
Education
Publications
STAIG: Spatial transcriptomics analysis via image-aided graph contrastive learning for domain exploration and alignment-free integration
Yang, Y., Cui, Y., Zeng, X., Zhang, Y., Loza, M., Park, S. J., & Nakai, K. (2025).
Nature Communications, 16(1), 1067.
Comparative single-cell transcriptomic analysis reveals putative differentiation drivers and potential origin of vertebrate retina
Zeng, X., Gyoja, F., Cui, Y., Loza, M., Kusakabe, T. G., & Nakai, K.
NAR Genomics and Bioinformatics, 6(4), lqae149 (2024).
Computational analysis of the functional impact of MHC-II-expressing triple-negative breast cancer
Cui, Y., Zhang, W., Zeng, X., Yang, Y., Park, S. J., & Nakai, K.
Frontiers in Immunology, 15, 1497251 (2024).
Diffusionst: A diffusion model-based framework for enhancing spatial transcriptomics data quality and identifying spatial domains
Cui, Y.*, Cui, Y.*, Wang, R., Nakai, K., Ye, X., Sakurai, T., & Wei, L.
Preprint, July 2024.
DenoiseST: A dual-channel unsupervised deep learning-based denoising method to identify spatial domains and functionally variable genes in spatial transcriptomics
Cui, Y., Wang, R., Zeng, X., Cui, Y., Zhu, Z., Nakai, K., … & Wei, L.
Preprint, March 2024.
HyGAnno: Hybrid graph neural network–based cell type annotation for single-cell ATAC sequencing data
Zhang, W., Cui, Y., Liu, B., Loza, M., Park, S. J., & Nakai, K.
Briefings in Bioinformatics, 25(3), bbae152 (2024).
Posters
Cui, Y., Zhang, W., Zeng, X., Yang, Y., Park, S. J., & Nakai, K.
Presented at: 1st Asia & Pacific Bioinformatics Joint Conference (APBJC2024), Oct 22-25, 2024, Okinawa, Japan.
Cui, Y., Nakai, K.
Presented at: The 46th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2023), Dec 6-8, 2023, Kobe, Japan.
Cui, Y., Nakai, K.
Presented at: The 21st Awaji International Forum on Infection and Immunity, Sep 3-6, 2023, Karuizawa, Japan.
Awards
SPRING GX Fellowship (JST) May 2024 – Mar 2025